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Metritis Recognition and Response: Managing Post-Calving Uterine Infection

How to recognize, treat, and prevent metritis in cattle, covering classification of uterine infections, risk factors, treatment protocols, and long-term reproductive impact.

RanchSafety Team January 20, 2026 12 min read

Uterine Infections After Calving Can Turn Deadly Fast, So Catch Them Early

Metritis (infection and inflammation of the uterus) is one of the most common and costly complications after calving. While some bacterial contamination happens in virtually all cows after calving, true metritis develops when the infection overwhelms the cow's defenses and makes her systemically sick. Catching it early and treating appropriately prevents life-threatening septicemia and minimizes long-term reproductive damage.

Understanding Metritis

Definition and Classification

TypeTimingDefinition
Puerperal metritis0-21 days post-calvingAbnormally enlarged uterus, fetid discharge, PLUS fever >103.5 F and systemic illness
Clinical metritis0-21 days post-calvingAbnormally enlarged uterus, purulent discharge, WITHOUT systemic signs
Clinical endometritis>21 days post-calvingPurulent or mucopurulent discharge, no systemic illness
Subclinical endometritis>21 daysInflammation without visible discharge (detected by cytology)
In a normal recovery, the uterus contracts and involutes, the immune system clears bacteria, and discharge decreases and clears over time. When things go wrong, toxins are produced and absorbed, the immune system gets overwhelmed, and systemic illness develops.

Common Bacteria Involved

The bacteria most commonly responsible for metritis are Escherichia coli (E. coli), Trueperella pyogenes (formerly Arcanobacterium pyogenes), Fusobacterium necrophorum, Prevotella species, and Bacteroides species. These bacteria often work together, creating a more severe infection than any single organism would cause.

Risk Factors

Pre-Calving Factors

FactorHow It Increases Risk
Poor body conditionImmunosuppression
Excessive body conditionMetabolic stress, difficult calving
Nutritional deficienciesImpaired immune function
Lack of pre-calving vaccinationNo scour vaccine = calf problems = more intervention
FactorWhy It Matters
DystociaTrauma, contamination, exhaustion
Assisted deliveryBacterial introduction
Cesarean sectionSurgical contamination, tissue trauma
Retained placentaBacterial growth medium
StillbirthAbnormal hormonal signals, often with intervention
TwinsLarger placental surface, more contamination
FetotomySevere contamination

Post-Calving Factors

FactorRisk Contribution
Milk feverImmunosuppression, reduced uterine contractions
KetosisImmunosuppression
Poor hygieneBacterial load
Continued manipulationFurther contamination

Recognition

Signs of Puerperal Metritis (Severe)

Systemic signs include depression or dullness, decreased appetite, reduced milk production, rapid heart rate, dehydration, and weakness or reluctance to rise. Local signs include watery (sometimes blood-tinged) discharge with a foul, fetid odor, an abnormally large uterus on palpation, and straining may be present.

Signs of Clinical Metritis (Less Severe)

Clinical metritis presents with purulent uterine discharge that may be odorous, a uterus that is larger than expected, but with the cow eating and behaving normally. The lack of systemic illness is what distinguishes it from puerperal metritis.

The Classic Presentation

A cow 5-10 days after calving (especially after a difficult birth or retained placenta) is off feed, dull, running a fever, and has foul-smelling discharge. That picture should immediately make you think metritis.

Timing Clues

TimingMost Likely Diagnosis
3-10 days post-calvingPuerperal metritis (if systemic signs)
7-21 days post-calvingClinical metritis
>21 days post-calvingEndometritis

Treatment

Puerperal Metritis (Systemic Illness)

Systemic antibiotics are the first-line treatment and must reach therapeutic levels in uterine tissue. Common choices (consult your veterinarian) include Ceftiofur, Ampicillin, Penicillin, and Oxytetracycline. Continue treatment until fever resolves and improvement is seen, following veterinary guidance on duration.

Supportive care includes fluids if dehydrated, maintaining appetite with palatable feed, and close monitoring of temperature and attitude.

Clinical Metritis (No Systemic Signs)

Some practitioners use intrauterine treatment for clinical metritis, and prostaglandins may be used if the cow is cycling (more than 2 weeks post-partum). Intrauterine therapy may be used in conjunction with systemic treatment but should not replace systemic antibiotics in severe cases.

Supportive Care

Provide fresh water, keep the cow in a clean environment, reduce stress, and monitor temperature and attitude daily. These basics help the cow's own immune system work alongside any antibiotics.

When to Call the Veterinarian

Call Immediately If:

  • Fever >104 F with depression
  • Cow not eating for more than 24 hours
  • Signs of shock (weak, cold extremities)
  • No improvement after 48 hours of treatment
  • Uncertain about diagnosis

Call for Guidance:

If this is your first time treating metritis, you have questions about antibiotic choice, the cow is high-value, or treatment isn't working, get your veterinarian involved. Early professional input often saves money and improves outcomes.

Prevention Strategies

Pre-Calving Management

Good nutrition is the foundation: adequate protein for immune function, a balanced mineral program, and Vitamin E and selenium supplementation if the cow is deficient. Calving ease management through appropriate sire selection and good observation protocols also reduces your risk.

At Calving

Keep things clean. Use clean equipment if assisting, provide lubrication if needed, and minimize intervention when possible. When assistance is required, use proper technique with clean hands, arms, and equipment.

Post-Calving

Monitor fresh cows for any signs of trouble. Check temperature if there's any concern and note the character of any discharge. Support recovery with good hydration, a clean environment, and minimal stress.

Complications

Short-Term Complications

Septicemia and toxemia from metritis can be rapidly fatal and require aggressive treatment. Peritonitis (very poor prognosis) usually results from uterine rupture or perforation. Both are emergencies.

Long-Term Reproductive Consequences

ConsequenceImpact
Delayed uterine involutionLonger to first heat
Chronic endometritisPersistent discharge, poor conception
Increased services per conceptionMore breeding attempts needed
Extended calving intervalLater next calf
PyometraPus accumulation, requires treatment

Fertility Impact

Cows that recover from metritis typically see days to first service increased by 7-14 days, services per conception increased by 0.3-0.5, and overall conception rates reduced by 15-20%. These numbers underscore why prevention is worth the effort.

Prognosis

Recovery Expectations

Discharge may persist for weeks after treatment, and full uterine recovery takes 4-8 weeks. Most cows can be bred, though fertility may be reduced for that cycle.

Outcome FactorGood PrognosisPoor Prognosis
SeverityClinical metritisPuerperal with toxemia
Treatment timingEarly treatmentDelayed treatment
ResponseQuick improvementPoor response
ComplicationsNonePeritonitis, chronic infection

Long-Term Decisions

Consider culling cows with chronic endometritis that won't resolve, severely compromised fertility, or repeated treatment failure. At some point, the ongoing cost of treatment and lost production outweighs the cow's value.

Comparison: Normal Post-Calving vs. Metritis

FeatureNormal Post-CalvingMetritis
Discharge colorRed to brown, clearingRed-brown to gray, not improving
Discharge odorMild, improvesFoul, fetid
Discharge volumeDecreasingMay persist or increase
FeverNone or mild first day>103.5 F
AppetiteNormalDecreased
AttitudeNormalDepressed
Milk productionNormalDecreased

Record Keeping

Document for Each Case

Record the cow identification, calving date and any complications, date signs were first noted, temperature readings, discharge description, treatment given (drug, dose, route, dates), response to treatment, outcome, and return to cycling and breeding data. Complete records let you identify patterns and improve your prevention strategies over time.

Use Records For

Your metritis records help you identify high-risk cows, evaluate treatment protocols, make culling decisions, and improve prevention strategies across the herd.

Metritis vs. Other Post-Calving Discharges

Decision Guide

Normal lochia shows a decreasing amount over 2 weeks, has a mild odor that improves, and the cow has no fever and feels fine. Clinical metritis produces purulent discharge that may be odorous, with no fever and the cow eating normally. Puerperal metritis often shows red-brown to gray discharge, fever above 103.5 F, and a cow that is depressed and off feed. Retained placenta may develop into metritis if infected, so monitor for fever.

Summary: Metritis Management Protocol

Day 0-3 Post-Calving

  • Monitor appetite and attitude
  • Note any discharge (normal vs. abnormal)
  • Temperature if any concern

If Signs Develop

  • Take temperature
  • Assess severity:
  • Fever + sick = Puerperal metritis (emergency)
  • No fever, eating = Clinical metritis (treat but less urgent)
  • Begin treatment:
  • Systemic antibiotics for puerperal metritis
  • Consider treatment for clinical metritis
  • Supportive care:
  • NSAIDs for fever/inflammation
  • Fluids if needed
  • Nutritional support

Monitor Response

  • Temperature should normalize within 24-48 hours
  • Appetite should improve
  • Discharge will take longer to resolve
  • If no improvement, consult veterinarian

The Bottom Line on Metritis

Metritis is a common and potentially serious complication of calving that needs quick recognition and the right treatment. The keys are knowing the risk factors (especially dystocia and retained placenta), watching fresh cows closely, telling the difference between normal post-calving discharge and infection, and treating systemically when fever and illness are present.

With good prevention practices and timely intervention, most cases of metritis can be treated successfully, though some hit to fertility should be expected.

References

  • Sheldon, I.M., et al. "Defining postpartum uterine disease in cattle." Theriogenology.
  • LeBlanc, S.J. "Postpartum uterine disease and dairy herd reproductive performance." The Veterinary Journal.
  • Azawi, O.I. "Postpartum uterine infection in cattle." Animal Reproduction Science.
  • University of Wisconsin-Madison. "Metritis in Dairy Cattle." vetmed.wisc.edu
  • Giuliodori, M.J., et al. "Metritis in dairy cows: Risk factors and reproductive performance." Journal of Dairy Science.
  • Beef Cattle Research Council. "Post-Calving Cow Management." beefresearch.ca
Article ID: 6.2.6